Synthesis of new biologically active arylfuranylmethyltriazinones and their antibacterial activity studies⁺

Abstract

In view of the pharmacological activities of 1,2,4-triazinones, a series of 4-amino-6-arylfurany lmcthyl-3-mercapto- 1 ,2,4- triazin-5(4<i>H</i>)-ones <b>7</b> have been synthesized by refluxing pyruvic acids <b>5</b> in ethanol with thiocarbohydrazide <b>6</b> on a steam-bath. The structures of <b>7</b> are confirmed by elemental analysis, IR, NMR and mass spectral data. Also, these compounds <b>7</b> have been screened for antibacterial activities against <i>E. coli, S.aureus, P. aeruginosa</i> and <i>G</i>.<i>bacillus. </i>Their MIC values are determined. The results indicate that among the compounds tested, compounds <b>7a</b> and <b>7c</b> carrying <i>p</i>-chloro and <i>p</i>-bromo substituents show excellent anti bacterial activity against all the bacteria tested. It is concluded that compounds <b>7a</b>, <b>7c,</b> <b>7d</b> and <b>7f</b> may prove to be promising antibacterial agents.