Synthesis and antimicrobial activity of 5-[(4-aroyl) aryloxymethyl]-2-(4- methylphenylamino)-1 ,3,4-thiadiazoles and 5-[(4-aroyl) aryloxy methyl]-4- (4-methylphenyl)-3-mercapto-4<i>H</i>-1,2,4-triazoles

Abstract

Aroyl aryloxyaeetic thiosemicarbazides <b>4a-d</b> have been synthesized by the reaction of acid hydrazides <b>3a-d</b> with <i>p</i>-tolyl isothiocyanate. The aroyl aryloxyacetic thiosemicarbazides <b>4a-d</b>

on intramolecular cyclization using cone. H₂SO₄ and 2<i>N </i>NaOH give 1,3,4-thiadiazoles <b>5a-d</b> and 3-mercapto-4<i>H</i>-1,2,4-triazoles <b>6a-d</b>, respectively. The structures of the synthesised compounds have been determined by their elemental analysis and spectral data. The synthesized compounds are evaluated for their antibacterial activity.