Please use this identifier to cite or link to this item:
http://nopr.niscpr.res.in/handle/123456789/21845| Title: | QSAR studies on anti HIV-1 N-substituted betulinic acid amides |
| Authors: | Srivastava, Arun K Shakeel, Mohd Khan, Arbab A |
| Issue Date: | Feb-2002 |
| Publisher: | NISCAIR-CSIR, India |
| Abstract: | QSAR studies, using structural parameters
such as equalized electronegativity 'Xeq', molecular connectivity ‘1 b'
and hydrophobicity ‘logP' on a novel series of ω-amino alkanoic acid derivatives
of betulinic acid, have been discussed. Anti HIV-1 activity of these compounds both
in CEM-4 and MT-4 cell cultures is found to correlate well with steric 1b
as well as electronic Xeq parameters. The
presence of an amide function is found to be
important for activity.
|
| Page(s): | 436-439 |
| ISSN: | 0975-0983(Online); 0376-4699(Print) |
| Appears in Collections: | IJC-B Vol.41B(02) [February 2002] |
Files in This Item:
| File | Description | Size | Format | |
|---|---|---|---|---|
| IJCB 41B(2) 436-439.pdf | 720.25 kB | Adobe PDF | View/Open |
Items in NOPR are protected by copyright, with all rights reserved, unless otherwise indicated.