<span style="font-size:14.0pt;line-height: 115%;font-family:"Times New Roman";mso-fareast-font-family:"Times New Roman"; color:black;mso-ansi-language:EN-IN;mso-fareast-language:EN-IN;mso-bidi-language: HI" lang="EN-IN">Diethylene glycol acrylate-<i>n</i>-vinyl pyrrolidone copolymer resins for bone cement applications</span>

Abstract

<span style="font-size:14.0pt;line-height: 115%;font-family:" times="" new="" roman";mso-fareast-font-family:"times="" roman";="" color:black;mso-ansi-language:en-in;mso-fareast-language:en-in;mso-bidi-language:="" hi"="" lang="EN-IN">Biodegradable and injectable monomer diethylene glycol acrylate (DGA) and diethylene glycol acrylate-<i>n</i> -vinyl pyrrolidone (DGA-VP) blends have been prepared and evaluated their suitability for bone cement applications. Studies on the setting of the monomer DGA and the blend DGA-VP have been carried out using a free radical initiator. Lower setting time is observed with the monomer in comparison with that of the blend. The degradation of cured PDGA and P(DGA- VP) polymeric materials has been evaluated in simulated physiological fluids. Studies on degradation in hydrolytic and oxidative media reveal faster degradation during initial period of aging followed by slower and steady state degradation. <i>In</i> <i>vitro </i>degradation studies show more hydrolytic degradation in PDGA while both hydrolytic and oxidative degradation in P(DGA-VP) in comparison to that of PDGA. Also, the biocompatible comonomer (VP) enhances biodegradation of aliphatic polyester PDGA.</span>