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http://nopr.niscpr.res.in/handle/123456789/22150| Title: | Heterocyclic systems containing bridgehead nitrogen atom: Synthesis and bioactivity of thiazolo[3,2-b]-s-triazoles and isomeric thiazolo[2, 3-c]-s-triazoles |
| Authors: | Mohan, Jag Anupama |
| Issue Date: | Jan-2001 |
| Publisher: | NISCAIR-CSIR, India |
| Abstract: | The reaction of 3-[p-(t-butyl phenyl)]-5-mercapto-s-triazole 2 with α-haloketones gives, in two steps, 5-substituted-2-[p-(t-butyl phenyl)] thiazolo[3, 2-b]-s-triazoles 4 and not the isomeric 5-substituted-3-[p-(t-butyl phenyl)] thiazolo[2, 3-c]-s-triazoles 6. Unequivocal synthesis of the latter has also been achieved by condensing 1-[p-(1-butylbenzoyl)]-3- thiosemicarbazide 1 with α-haloketones, which furnishes in first step, 2-[p-(t-butylbenzoyl)] hydrazino-4-(substituted phenyl)thiazole hydro-bromides 5 and not the alternative 2-[p-(t-butyl benzoyl)]hydrazino-5-(substituted pheyl) thiazole hydrobromides. The former compounds, on treatment with phosphoryl chloride undergo facile cyclization to yield 6. Their antibacterial and antifungal activities have also been studied. |
| Page(s): | 54-56 |
| ISSN: | 0975-0983(Online); 0376-4699(Print) |
| Appears in Collections: | IJC-B Vol.40B(01) [January 2001] |
Files in This Item:
| File | Description | Size | Format | |
|---|---|---|---|---|
| IJCB 40B(1) 54-56.pdf | 610.98 kB | Adobe PDF | View/Open |
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