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http://nopr.niscpr.res.in/handle/123456789/22162| Title: | Synthsis of hemin and porphyrin derivatives and their evaluation for anticancer activity |
| Authors: | Sondhi, Sham M Singhal, Nidhi Verma, Rajeshwar P Arora, Sudershan K Dastidar, Sunanda G |
| Issue Date: | Feb-2001 |
| Publisher: | NISCAIR-CSIR, India |
| Abstract: | N, Ethylaminoadenosine, histamine, 2-amino-2-thiazoline, 4-aminoantipyrine, sulphathiazole and a number of 3,4-diaryl-2-iminothiazolines are coupled with hemin to give bis coupled products 3a, 3b, 3c, 3d, 3e and 3f-m, respectively. Mono coupling of 2-amino-2-thiazoline with hemin gives isomeric mixture of mono coupled product 4. Deuteroporphyrin IX dicarboxylic acid is coupled with 2-amino-2-thiazoline to give bis coupled product 6 which on treatment with MnCl2,4H2O gives compound 7. Compounds 3a-m and 4 have been screened for anticancer activity against a small panel of six cancer cell lines consisting of prostate tumour (DU 145, PC3), colon carcinoma (HT29 or SW620), melanoma (SK-MEL-5, LOX), breast cancer (MCF 7 and adriamycin resistant MCF 7), CNS (U251) and ovarian cancer (IGROV1). Best GI50 (concentration which inhibits the cell growth by 50%), values are shown by 3f, 6.3μM (prostate tumour, cell line DU 145); 3f, 6.1 μM (colon tumor, cell line HT29); 4, 2.09 μM (colon tumor, cell line SW620); 3f, 2.2 μM (melanoma tumor, cell line LOX); 3i, 4.4μM (breast tumor, cell line MCF7/ADR); 3j, 2.68μM (ovarian tumor, cell line IGROV1) and 3g, 1.25μM (CNS tumor, cell line U 251) respectively. |
| Page(s): | 113-119 |
| ISSN: | 0975-0983(Online); 0376-4699(Print) |
| Appears in Collections: | IJC-B Vol.40B(02) [February 2001] |
Files in This Item:
| File | Description | Size | Format | |
|---|---|---|---|---|
| IJCB 40B(2) 113-119.pdf | 3.22 MB | Adobe PDF | View/Open |
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