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http://nopr.niscpr.res.in/handle/123456789/22275| Title: | Temperature controlled stereospecific epoxidation of 5-adrosten-3β, 17β-diol diacetate. Preparation of 6α-and 6β-substituted androstane derivatives |
| Authors: | Srivastava, Brijesh Kumar Kumar, Atul Dwivedy, I Ray, Suprabhat |
| Issue Date: | May-2001 |
| Publisher: | NISCAIR-CSIR, India |
| Abstract: | Reaction of 5-adrosten-3β, 17β-diol diacetate with m-chloroperbenzoic acid at different temperatures and pH in a biphasic system with NaHCO3 as a phase transfer catalyst yields corresponding 5α, 6α- and 5β, 6β-epoxides, which could be separated by column chromatography. Exclusive formation of 5a, 6a-epoxide could be obtained at a low temperature (-20°C). Epoxides on treatment with different amines lead to stereospecific opening, the amino substituent entering from the opposite side at C-6. |
| Page(s): | 410-413 |
| ISSN: | 0975-0983(Online); 0376-4699(Print) |
| Appears in Collections: | IJC-B Vol.40B(05) [May 2001] |
Files in This Item:
| File | Description | Size | Format | |
|---|---|---|---|---|
| IJCB 40B(5) 410-413.pdf | 1.75 MB | Adobe PDF | View/Open |
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