Please use this identifier to cite or link to this item:
http://nopr.niscpr.res.in/handle/123456789/22393| Title: | New antihistaminic agents : Part 6-Synthesis and H1 -antihistaminic evaluation of 3-[(N,N -dialkylamino )alkyl]-6-halo-2-phenyl-3,4-dihydroquinazolin-4(3H)-ones† |
| Authors: | Singh, S Dev Raju, M Bhagavan Bahekar, Rajesh H Rajan, K S Rao, A Raghu Ram |
| Issue Date: | Sep-2001 |
| Publisher: | NISCAIR-CSIR, India |
| Abstract: | Eight new 3-(N,N-dialkylamino)alkyl derivatives of 2-phenyl-3,4-dihydroquinazolin-4(3H)-ones 3a-h have been synthesized as antihistaminic agents. They have been characterized by elemental analyses and spectral (IR, 1H NMR and mass) data. The in vitro and in vivo H1-antihistaminic potencies of 3a-h have been evaluated by isolated guinea pig ileum method and histamine chamber method respectively. Among the compounds tested compound 3d is found to be the most potent with the percentage protection (in vivo) 74.77% and IC50 (in vitro) 1.3×10-3 g/L. |
| Page(s): | 813-816 |
| ISSN: | 0975-0983(Online); 0376-4699(Print) |
| Appears in Collections: | IJC-B Vol.40B(09) [September 2001] |
Files in This Item:
| File | Description | Size | Format | |
|---|---|---|---|---|
| IJCB 40B(9) 813-816.pdf | 2.06 MB | Adobe PDF | View/Open |
Items in NOPR are protected by copyright, with all rights reserved, unless otherwise indicated.