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http://nopr.niscpr.res.in/handle/123456789/22466| Title: | Synthesis of 4-carbethoxy-4H-3-substitutedisoxazol-5-ones and their conversion into novel spiroheterocycles |
| Authors: | Chande, Madhukar S Bhat, Udayashankar S |
| Issue Date: | Jan-2000 |
| Publisher: | NISCAIR-CSIR, India |
| Abstract: | Interaction of diethyl α-acyl/aroylmalonates 1 with hydroxylamine hydrochloride 2 afford 4-carbethoxy-4H-3-substituted isoxazol-5-ones 3 and 3-substitu ted-4H-5-oxo-isoxazol-4- carboxylic acids 4. Bromination of 3 affords 4-bromo derivatives 5, which with thiocarbamides. 4-substituted thiosemicarbazides give 2-alkyl/arylimino-4, 9-dioxo-3, 7-diaza-8-oxa-6-substituted-1-thia-(3H)-spiro[4,4]nonan-6,enes 7 and 2-alkyl/arylimino-5, 10-diox(l-9-oxa-7-substituted-l-thia-3, 4, 8-triaza-(3H, 4H)- spiro[5,4]dec-7-enes 8. Characterisation of the products has been done on the basis of spectral (IR,1H NMR and 13C NMR) data. |
| Page(s): | 68-70 |
| ISSN: | 0975-0983(Online); 0376-4699(Print) |
| Appears in Collections: | IJC-B Vol.39B(01) [January 2000] |
Files in This Item:
| File | Description | Size | Format | |
|---|---|---|---|---|
| IJCB 39B(1) 68-70.pdf | 609.5 kB | Adobe PDF | View/Open |
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