Please use this identifier to cite or link to this item: http://nopr.niscpr.res.in/handle/123456789/22476
Title: Study on developmental toxicity and behavioral safety of Streblus asper Lour. bark on Zebrafish embryos
Authors: Kumar, R B Suresh
Kar, Biswakanth
Dolai, Narayan
Haldar, Pallab Kanti
Keywords: Streblus asper;Moraceae;Zebrafish embryos;Developmental toxicity;Chorion;Behavioral safety
Issue Date: Sep-2013
Publisher: NISCAIR-CSIR, India
IPC Code: Int. cl. (2011.01)−A61K 36/00
Abstract: Streblus asper Lour. is a medicinal plant commonly found in Asia and traditionally used for a wide range of diseases. Therefore, evaluation of toxicological parameter is essential for future reference studies. In our present study methanol extract of S. asper bark (MESA) was evaluated for its developmental toxicity and behavioral safety on Zebrafish embryos up to 72 h post fertilization (hpf). This report provides the first examination of observable MESA effect on zebrafish embryos. Present study reveals the increase of heart rate directly proportional to the increase of MESA dosage with slight oedema of heart muscle at higher dose, and precautions must be taken for further use by pregnant women.
Page(s): 255-259
ISSN: 0976-0512 (Online); 0976-0504 (Print)
Appears in Collections:IJNPR Vol.4(3) [September 2013]

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