Microwave-assisted synthesis and biological activities of some 7/9-substituted-4-(3-alkyl/aryl-5,6-dihydro-<i>s</i>-triazolo[3,4-<i>b</i>][1,3,4] thiadiazol-6-yl)tetrazolo[1,5-<i>a</i>]quinolines

Abstract

A series of novel 7/9-substituted-4-(3-alkyl/aryl-5,6-dihydro-<i>s</i>-triazolo[3,4-<i>b</i>] [1,3,4] thiadiazol-6-yl)tetrazolo[1,5-<i>a</i>]quinolines <b>3</b> have been synthesised by the condensation of 7/9-substituted-4-formyltetrazolo[1,5-<i>a</i>]quinolines <b>1</b> with 5-substituted-4-amino-3-mercapto-1,2,4-triazoles <b>2 </b>under microwave irradiation using basic alumina as solid support or by<i> </i>stirring in DMF. 7/9-Substituted-4-formyltetrazolo[1,5-<i>a</i>]quinolines <b>1</b> are prepared from 6/8-substituted-2-chloro-3-<i> </i>formylquinolines by stirring in DMSO containing sodium azide, water and acetic acid. The synthesised compounds have<i> </i>been characterized on the basis of elemental and spectral studies and screened for their antifungal, antibacterial and anti-inflammatory<i> </i>activities.