Entroenthalpics: New model for solving solubility problem of high molecular weight biocompatible PVP macromolecules

Abstract

PVP of 10,000; 29,000; 40,000 and 55,000 g/mol of their 0.001, 0.003, 0.005, 0.007 and 0.009 mass fractions separately were solubilized in water at <i>T </i>= (293.15, 298.15, 303.15 and 308.15) K at an interval of 50 C temperature. The solubility has been a primary parameter for preparing their mixtures with water for industrial applications. Since, solubility and physicochemical properties (PCP) are closely associated for useful formulations. Thus, in the present work their densities, viscosities, surface tension, sound velocity, refractive index and UV absorption study are reported. The density increases by 0.04 % with an increase in mass fraction by 0.002, irrespective of the molecular weights of PVP. In general, on increasing the concentration of PVP; the

increase in viscosity is 1.44; 2.67; 3.69 and 3.81 % at <i>T </i>= (293.15 to 308.15) K, respectively. Analysis of UV absorption reveals the stabilization at 220 nm for PVP 10,000 and the absorption maxima is less than PVP 10,000 by 0.468. At an arbitrary point 1.5 on absorbance scale the wavelength is being narrowed down by 21, 11, 9, and 9 nm with an increase in molecular weights, reveals that UV light is unable to influence interacting behaviour of PVP higher molecular weights.