Effects of deltamethrin on granule cell migration during postnatal development of rat cerebellum

Abstract

Deltamethrin (DLT; 0.7mg/kg/body wt/day, <i>ip, </i>dissolved in propylene glycol) administration during postnatal days 9-13 in Albino rat pups, resulted in a delayed appearance of radial glial fibers, that guide the mi gration of granule cells. Moreover, the radial glial fibers in the DLT-treated pups were disorganized, hypertrophied and heavily stained. Thus, it is being proposed that although after exposure to DLT the neuronal proliferation occurs at normal rate, the neuronal migration along the stumpy and crumpled radial fibers hamper the journey of the healthy neurons to their proper destination.