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Title: In vivo induction of sister chromatid exchanges (SCEs) and chromosomal aberrations (CAs) by lynestrenol
Authors: Siddique, Yasir Hasan
Afzal, Mohammad
Keywords: Chromosomal aberrations;Genotoxicity;Lynestrenol;Mouse bone marrow cells;Sister chromatid exchanges
Issue Date: Mar-2005
Publisher: NISCAIR-CSIR, India
Abstract: Genotoxicity study of synthetic progestin lynestrenol, was carried out on mouse bone marrow cells using sister chromatid exchanges (SCEs) and chromosomal aberrations (CAs) as parameters. Lynestrenol was studied at three different doses (6.87, 13.75 and 27.50 mg/kg body wt.). SCE and CA increased significantly as compared to normal control when treated with lynestrenol at 13.75 and 27.50 mg/kg body wt. The present results suggest that lynestrenol has both a genotoxic and cytotoxic effects in mouse bone marrow cells.
Page(s): 291-293
ISSN: 0975-1009 (Online); 0019-5189 (Print)
Appears in Collections:IJEB Vol.43(03) [March 2005]

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