Please use this identifier to cite or link to this item:
http://nopr.niscpr.res.in/handle/123456789/23155| Title: | Prevention of chromate induced oxidative stress by alpha-lipoic acid* |
| Authors: | Budhwar, Roli Kumar, Sushil |
| Keywords: | Chemoprevention;Lipoic acid;Oxidative stress;Potassium dichromate |
| Issue Date: | Jun-2005 |
| Publisher: | NISCAIR-CSIR, India |
| Abstract: | The parenteral administration of alpha-lipoic acid (LA) protected against chromate induced oxidative stress in mouse liver. A shift in Cr induced pro-oxidant state to antioxidant-state by LA was noteworthy. The degree of protection was significant and similar in different LA administration regimens (prior-, co- and post- parenteral Cr exposure) explored. An improved status of the tissue antioxidants by LA appeared to be the mechanism of mitigation. The results are of chemopreventive value and suggest a possible alternative to ascorbic acid for abrogation of Cr toxicity. |
| Page(s): | 531-535 |
| ISSN: | 0975-1009 (Online); 0019-5189 (Print) |
| Appears in Collections: | IJEB Vol.43(06) [June 2005] |
Files in This Item:
| File | Description | Size | Format | |
|---|---|---|---|---|
| IJEB 43(6) 531-535.pdf | 1.41 MB | Adobe PDF | View/Open |
Items in NOPR are protected by copyright, with all rights reserved, unless otherwise indicated.