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http://nopr.niscpr.res.in/handle/123456789/23159| Title: | Synthesis, antibacterial and antifungal activity of 2-amino-1,4-naphthoquinones using silica-supported perchloric acid (HClO4-SiO2) as a mild, recyclable and highly efficient heterogeneous catalyst† |
| Authors: | Sharma, Upendra Katoch, Deepali Sood, Swati Kumar, Neeraj Singh, Bikram Thakur, Archana Gulati, Arvind |
| Keywords: | 2-Amino-1,4-naphthoquinones;Antimicrobial activity;Heterogeneous catalyst;Silica-supported perchloric acid;Ultrasonication |
| Issue Date: | Nov-2013 |
| Publisher: | NISCAIR-CSIR, India |
| Abstract: | Perchloric acid adsorbed on silica gel (1 mol%) has been found to be an efficient and recyclable heterogeneous catalyst for rapid conjugate addition of primary and secondary amines with 1,4-naphthoquinone to afford 2-amino-1,4-naphthoquinones under ultrasonication in moderate to high yields without using any solvent. The compounds tested for in vitro antimicrobial activity have shown high antibacterial activity against Gram positive bacteria Bacillus subtilis, Micrococcus luteus, Staphylococcus aureus as compared to Gram negative bacteria Burkholderia cepacia, Escherichia coli, Enterobacter cloacae, Klebseilla pneumoniae and Pseudomonas aeruginosa. High antifungal activity has been observed against Candida albicans and Issatchenkia orientalis for all the compounds. |
| Page(s): | 1431-1440 |
| ISSN: | 0975-0983(Online); 0376-4699(Print) |
| Appears in Collections: | IJC-B Vol.52B(11) [November 2013] |
Files in This Item:
| File | Description | Size | Format | |
|---|---|---|---|---|
| IJCB 52B(11) 1431-1440.pdf | 95.11 kB | Adobe PDF | View/Open |
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