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http://nopr.niscpr.res.in/handle/123456789/23328| Title: | Fatty acids derived from a marine crustacean Diogenes avarus (Heller) and their antiangiogenic activity |
| Authors: | Pathare, Sujala Indap, Madhavi |
| Keywords: | Antiangionic activity;Diogenes avarus;Fatty acids |
| Issue Date: | Jun-2003 |
| Publisher: | NISCAIR-CSIR, India |
| Abstract: | An organic extract from a marine crustacean D. avarus was examined for antiangiogenic activity by using the chick embryo chorioallantoic membrane (CAM) assay. The methanol extract (HCM) inhibited angiogenesis in a dose dependent manner. The extract was further fractionated by bioactivity-guided separation to purify the active fractions successively. This resulted in three fractions HCM1, HCM2 and HCM3. The 50% inhibition shown by HCM was 600ng/disc, HCM 1 was 100ng/disc and of HCM3 was 2.7ng/disc. HCM3 which was separated by column chromatography and showed single spot on TLC was analysed by GLC and showed the presence of saturated and unsaturated fatty acids such as lauric, myristic, palmitic, stearic, oleic, linoleic. The antiangiogenic activity of the fatty acids obtained from a marine crustacean is reported for the first time. |
| Page(s): | 632-635 |
| ISSN: | 0975-1009 (Online); 0019-5189 (Print) |
| Appears in Collections: | IJEB Vol.41(06) [June 2003] |
Files in This Item:
| File | Description | Size | Format | |
|---|---|---|---|---|
| IJEB 41(6) 632-635.pdf | 959.29 kB | Adobe PDF | View/Open |
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