Please use this identifier to cite or link to this item:
http://nopr.niscpr.res.in/handle/123456789/23350| Title: | Inhibitory effect of manganese on contraction of isolated rat aorta |
| Authors: | Ettarh, R R |
| Keywords: | Calcium;MnCl2;Vascular contraction |
| Issue Date: | Feb-2004 |
| Publisher: | NISCAIR-CSIR, India |
| Abstract: | The effects of MnCl2 on vascular smooth muscle contraction induced by noradrenaline (NA) and KCl were investigated. Rings segments from rat aorta were isolated and changes in isometric tension recorded. MnCl2 (10 μM and 1 mM) significantly attenuated the contractile responses to NA and KCl. There were also reductions in the contractile responses to CaCl2 in NA- and KCl-stimulated rings, after pretreatment with MnCl2. The magnitude of the phasic contraction to NA was significantly reduced in presence of MnCl2. The results suggest that MnCl2 inhibits vascular smooth muscle contraction by influencing a Ca2+-mediated mechanism. |
| Page(s): | 149-151 |
| ISSN: | 0975-1009 (Online); 0019-5189 (Print) |
| Appears in Collections: | IJEB Vol.42(02) [February 2004] |
Files in This Item:
| File | Description | Size | Format | |
|---|---|---|---|---|
| IJEB 42(2) 149-151.pdf | 842.69 kB | Adobe PDF | View/Open |
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