Protective effect of <i>Terminalia chebula </i>against experimental myocardial injury induced by isoproterenol

Abstract

Cardioprotective effect of ethanolic extract of <i>Terminalia chebula </i>fruits (500 mg/kg body wt) was examined in isoproterenol (200 mg/kg body wt) induced myocardial damage in rats. In isoproterenol administered rats, the level of lipid peroxides increased significantly in the serum and heart. A significant decrease was observed in the activity of the myocardial marker enzymes with a concomitant increase in their activity in serum. Histopathological examination was carried out to confirm the myocardial necrosis. <i>T. chebula </i>extract pretreatment was found to ameliorate the effect of isoproterenol on lipid peroxide formation and retained the activities of the diagnostic marker enzymes.