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Title: D2-dopamine receptor and α2,adrenoreceptor-mediated analgesic response of quercetin
Authors: Naidu, Pattipati S
Singh, Amanpreet
Kulkarni, Shrinivas K
Keywords: Antinociceptive action;α2-adrenoreceptors;D2- dopamine receptors;Pain perception;Quercetin
Issue Date: Dec-2003
Publisher: NISCAIR-CSIR, India
Abstract: Quercetin, a biof1avonoid (100-300 mg/kg) produced dose dependent increase in tail-flick latency, the analgesic effect being sensitive to reversal by naloxone (1 mg/kg). Prior treatment with haloperidol (1 mg/kg),D1/D2 receptor antagonist haloperidol, sulpiride (50 mg/kg), a selective D2 receptor antagonist, yohimbine (5 mg/kg), a α2-adrenoreceptor  antagonist but not by SCH 23390 a, selective D1 receptor antagonist blocked this response. Apomorphine (1 mg/kg) a mixed D1/D2 dopamine receptor agonist, and quinpirole (0.5 mg/kg), a selective D2 receptor agonist also produced antinociception, that was reversed by haloperidol (1 mg/kg), sulpiride (50 mg/kg), but not by yohimbine (5 mg/kg). The antinociceptive action of quercetin (200 mg/kg) was potentiated by D2 agonist quinpirole (0.2 mg/kg). Dopamine D1 receptor agonist SKF38393 (10 and 15 mg/kg) failed to alter the antinociceptive effect of quercetin (200 mg/kg). Quercetin (200 mg/kg) reversed reserpine (2 mg/kg-4 hr) induced hyperalgesia, which was reversed by sulpiride but not by yohimbine. Thus, a role of dopamine D2 and  α2 adrenoreceptors is postulated in the antinoeiceptive action of quercetin.
Page(s): 1400-1404
ISSN: 0975-1009 (Online); 0019-5189 (Print)
Appears in Collections:IJEB Vol.41(12) [December 2003]

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