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Title: Antinociceptive action of FK506 in mice
Authors: Singh, Amanpreet
Kumar, Gaurav
Naidu, Pattipati S
Kulkarni, Shrinivas K
Keywords: Antinociception;FKS06;Mice
Issue Date: Dec-2003
Publisher: NISCAIR-CSIR, India
Abstract: Immunophilins are abundantly present in the brain as compared to the immune system. Immunophilin-binding agents like FKS06 are known to inactivate neuronal nitric oxide synthase (nNOS) by inhibiting calcineurin and decrease the production of nitric oxide. Nitric oxide is involved in the mediation of nociception at the spinal level. In the present study, the effect of FKS06 on the tail flick response in mice and the possible involvement of NO-L-arginine pathway in this paradigm was evaluated. FKS06 (0.5, 1 and 3 mg/kg, ip) produced a significant antinociception in the tail flick test. Nitric oxide synthase (NOS) inhibitor L-NAME significantly and dose dependently (10-40 mg/kg, ip) potentiated the FKS06 (0.5 mg/kg)-induced antinocieeption. On the other hand, NOS substrate L-arginine (100, 200 and 400 mg/kg) inhibited the FKS06-induced antinociception in a dose-dependent manner. Concomitant administration of L-NAME (20 and 40 mg/kg) with L-arginine (200 mg/kg) blocked the inhibition exerted by L-arginine on the FKS06-induced antinociception. Thus, it was concluded that NO- L-arginine pathway may be involved in the FKS06-induced antinociception in tail flick test.
Page(s): 1405-1409
ISSN: 0975-1009 (Online); 0019-5189 (Print)
Appears in Collections:IJEB Vol.41(12) [December 2003]

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