Effect of supplementary feeding of vitamin K_l on difethialone treated Indian gerbil, <i>Tatera indica </i>Hardwicke in laboratory

Abstract

Two dosages (1 and 2 mg/kg) of vitamin K₁ supplementation for 5 and 15 days were given to Indian gerbil <i>T. indica </i>fed on difethialone bait (0.0025%) for one day. The results indicated that the lower dosage could not reverse the<i> </i>anticoagulation process, however the period of mortality was considerably increased from 3-9 days (in control) to 5-14 days<i> </i>(5 days supplementation regime). Subsequently when the vitamin K₁ dosage was doubled and given for 15 days, there was<i> </i>100% reversal of anticoagulation process and all the test gerbils became normal within a month of poisoning with<i> </i>difethialone bait.