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Title: Antigenotoxic effect of allicin against SCEs induced by methyl methanesulphonate in cultured mammalian cells
Authors: Siddique, Yasir Hasan
Afzal, Mohammad
Keywords: Allicin;Allium sativum;Mammalian cells;Methyl methanesulphonate;Sister-chromatid exchange;Antigenotoxicity
Issue Date: Apr-2004
Publisher: NISCAIR-CSIR, India
IPC Code: Int. Cl.7 A61 K35/00
Abstract: Allicin, one of the sulphur compounds of garlic (Allium salivum), possesses antioxidant and thiol disulphide exchange activity and is also shown to cause a variety of activities potentially useful for human health. In this investigation, the effect of 1,5,10 and 20μM of allicin was determined for inhibiting the rate of SCE induced by 60μM of MMS. Cultured human lymphocytes from two female donors were used for the experiment. The levels of SCEs were lowered by allicin suggesting its antigenotoxic activity in mammalian cells in vitro.
Page(s): 437-438
ISSN: 0975-1009 (Online); 0019-5189 (Print)
Appears in Collections:IJEB Vol.42(04) [April 2004]

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