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http://nopr.niscpr.res.in/handle/123456789/23436| Title: | Influence of histamine and H1-receptor antagonists on ejaculated human spermatozoa: Role of intrasperm Ca2+ |
| Authors: | Gupta, A Khosla, R Gupta, S Tiwary, A K |
| Keywords: | Dichlorobenzamil;H1-receptor antagonists;Human sperm motility Histamine;Intrasperm calcium |
| Issue Date: | May-2004 |
| Publisher: | NISCAIR-CSIR, India |
| IPC Code: | Int. Cl7: A61K |
| Abstract: | Histamine reduced sperm viability in a dose- and time-dependent manner, accompanied by rise in intrasperm Ca2+. Further, 2', 4'-dichlorobenzamil hydrochloride (DBZ), a Na+-Ca2+ exchange inhibitor, known to elevate intrasperm Ca2+, potentiated both, elevation of intrasperm Ca2+ and spermicidal action of histamine. Pretreatment of sperm with very low doses of HI-receptor antagonists (chlorpheniramine, promethazine or diphenhydramine) prevented the histamine-induced elevation of intrasperm Ca2+ as well as its spermicidal action. However, pretreatment with famotidine, a H2-receptor antagonist did not produce such a protective action. The results strongly suggest that histamine elicits its spermicidal action via H1-receptors present on sperm cells. |
| Page(s): | 481-485 |
| ISSN: | 0975-1009 (Online); 0019-5189 (Print) |
| Appears in Collections: | IJEB Vol.42(05) [May 2004] |
Files in This Item:
| File | Description | Size | Format | |
|---|---|---|---|---|
| IJEB 42(5) 481-485.pdf | 2.67 MB | Adobe PDF | View/Open |
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