Anti-nociceptive effect of synthesized di-hydroxy flavones: Possible mechanism

Abstract

<span style="font-size: 13.0pt;mso-bidi-font-size:8.0pt;font-family:" times="" new="" roman","serif""="">Renewed interest on the research on the flavonoids is gaining more importance. Earlier literature on flavonoids indicated a significant anti-nociceptive action for flavones and mono-substituted flavones. However, they exhibited a ceiling effect. The present study was undertaken by new synthesizing six disubstituted flavones (DHFs) since poly substituted ones are expected to produce more potent effect. Their anti-nociceptive effect and the role of opioid involvement were studied using acetic acid induced abdominal constriction assay. All the six DHFs administered in elicited a dose related inhibition of

<span style="font-size: 13.0pt;mso-bidi-font-size:8.0pt;font-family:" times="" new="" roman","serif""="">abdominal constructions indicating the presence of the anti-nociceptive response. However, these substances also showed a similar ceiling effect. Like other flavonoid substances, they also utilized opioid pathways. It is suggested that these newly

<span style="font-size:13.0pt;mso-bidi-font-size:8.0pt; line-height:115%;font-family:" times="" new="" roman","serif""="">synthesized DHFs can be included along with other flavonoids while attempting clinical trial for analgesic use.<span style="font-size:16.0pt;mso-bidi-font-size:11.0pt; line-height:115%">

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