Please use this identifier to cite or link to this item:
http://nopr.niscpr.res.in/handle/123456789/23629| Title: | Enhancer aided in vitro permeation of atenolol and prazosin hydrochloride through mice skin |
| Authors: | Reddy, L Harivardhan Ghosh, Bijaya |
| Issue Date: | Jan-2001 |
| Publisher: | NISCAIR-CSIR, India |
| Abstract: | Effect of penetration enhancers were studied on the permeation of antihypertensive drugs prazosin hydrochloride and atenolol through full thickness skin of swiss albino mice. Atenolol was delivered to skin from saturated alcoholic solution containing 5% of 1-decanol and alcohol alone, while prazosin hydrochloride was saturated in dimethyl formamide(DMF, 5% v/v in water) and dimethyl sulfoxide(DMSO, 5% v/v in water). Atenolol permeation was augmented significantly in decanolic solution and also in pure alcohol. In case of prazosin hydrochloride, significant enhancement of permeation was shown by DMSO but not by DMF. |
| Page(s): | 47-51 |
| ISSN: | 0975-1009 (Online); 0019-5189 (Print) |
| Appears in Collections: | IJEB Vol.39(01) [January 2001] |
Files in This Item:
| File | Description | Size | Format | |
|---|---|---|---|---|
| IJEB 39(1) 47-51.pdf | 958.88 kB | Adobe PDF | View/Open |
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