Anticonvulsant effect of cytoskeletal depolymerizers in combination with potassium channel opener and adenylate cyclase activator; a causative link with nerve growth factor?

Tyagi, Manoj G; Jose, Vinu M

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Please use this identifier to cite or link to this item: http://nopr.niscpr.res.in/handle/123456789/23743

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DC Field	Value	Language
dc.contributor.author	Tyagi, Manoj G	-
dc.contributor.author	Jose, Vinu M	-
dc.date.accessioned	2013-11-19T05:54:18Z	-
dc.date.available	2013-11-19T05:54:18Z	-
dc.date.issued	2001-05	-
dc.identifier.issn	0975-1009 (Online); 0019-5189 (Print)	-
dc.identifier.uri	http://hdl.handle.net/123456789/23743	-
dc.description	425-430	en_US
dc.description.abstract	Anticonvulsant effect of cytoskeletal depolymerizing drugs in combination with potassium channel (K_ATP) opener and adenylate cyclase activator was evaluated in animal models of epilepsy. Seizures were induced in the animals by subjecting them to maximal electroshock (MES) or by injecting a chemical convulsant, pentylenetetrazole (PTZ). Moreover a correlation with the nerve growth factor (NGF) was also investigated. The anticonvulsant effect of minoxidil (1200µg/kg i.p) and Deacetylforskolin (600 µg/kg i.p) was significantly enhanced in the mice pre-treated with cytoskeletal depolymerizing drugs. On the other hand nerve growth factor potentiated the convulsive phenomenon and decreased the seizure threshold in both the electroshock and chemically induced convulsions. Another interesting feature was the interaction of cytochalasin B, a microfilament disrupter in preventing the action of mNGF and PTZ. This study demonstrates the importance of interaction between cytoskeletal structures and signaling molecules in determining the convulsive threshold. This study clearly points to the importance of the nerve growth factor in convulsive phenomenon.	en_US
dc.language.iso	en_US	en_US
dc.publisher	NISCAIR-CSIR, India	en_US
dc.rights	CC Attribution-Noncommercial-No Derivative Works 2.5 India	en_US
dc.source	IJEB Vol.39(05) [May 2001]	en_US
dc.title	Anticonvulsant effect of cytoskeletal depolymerizers in combination with potassium channel opener and adenylate cyclase activator; a causative link with nerve growth factor?	en_US
dc.type	Article	en_US
Appears in Collections:	IJEB Vol.39(05) [May 2001]

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