<span style="font-size: 19.0pt;mso-bidi-font-size:14.0pt;font-family:"Times New Roman","serif"">Acute and subchronic toxicity of aflatoxin B₁ <span style="font-size:14.0pt;mso-bidi-font-size:9.0pt;font-family:"Times New Roman","serif""> <span style="font-size:19.0pt; mso-bidi-font-size:14.0pt;font-family:"Times New Roman","serif"">to rohu, <i><span style="font-size:19.5pt;mso-bidi-font-size:14.5pt;font-family:"Times New Roman","serif"">Labeo rohita </span></i><span style="font-size:19.0pt;mso-bidi-font-size:14.0pt; font-family:"Times New Roman","serif"">(Hamilton) </span></span></span></span>

Abstract

<span style="font-size: 13.0pt;mso-bidi-font-size:8.0pt;font-family:" times="" new="" roman","serif""="">Pathological alterations in various organs of rohu <i><span style="font-size:13.5pt; mso-bidi-font-size:8.5pt;font-family:" times="" new="" roman","serif""="">(L.rohita) </span></i><span style="font-size:13.0pt;mso-bidi-font-size:8.0pt;font-family:" times="" new="" roman","serif""="">fingerlings following acute (0,7.50, 11 .25 and 13.75 mg/kg body weight) and subchronic (0, 1.25 and 2.50 mg/kg body weight) single ip aflatoxin B <span style="font-size:10.5pt;mso-bidi-font-size:5.5pt;font-family:" times="" new="" roman","serif""="">1 <span style="font-size:13.0pt;mso-bidi-font-size:8.0pt;font-family:" times="" new="" roman","serif""="">exposure for I 0 and 90 days, respectively, were investigated. Mortality (dose-dependent) was marked only during acute toxicosis. The changes observed in various organs were dose and time dependent. The acute dose groups revealed toxic changes <i><span style="font-size:13.5pt;mso-bidi-font-size:8.5pt; font-family:" times="" new="" roman","serif""="">viz., </span></i><span style="font-size: 13.0pt;mso-bidi-font-size:8.0pt;font-family:" times="" new="" roman","serif""="">necrotic and vascular changes in liver and gill lamellae; meningitis, congestion in brain, degeneration and inflammatory reaction in heart along with degenerative to necrotic changes in kidney tubules and sloughing of the intestinal mucosa. During subchronic exposure to this toxin, preneoplastic lesions in liver along with changes in spleen, intestine, gi ll and pancreas were recorded. With low

<span style="font-size: 13.0pt;mso-bidi-font-size:8.0pt;font-family:" times="" new="" roman","serif""="">doses of aflatoxin, the fish did not reveal any mortality or external signs other than catchexia and increased pigmentation on scales. In composite culture practice of Indian major carps, this could be of economic significance.

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