Effect of ATP sensitive potassium channel modifiers on antinociceptive effect of metoclopramide

Reddy, PM K; Shantanu, S; Shewade, D G; Ramaswamy, S

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Please use this identifier to cite or link to this item: http://nopr.niscpr.res.in/handle/123456789/23755

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DC Field	Value	Language
dc.contributor.author	Reddy, PM K	-
dc.contributor.author	Shantanu, S	-
dc.contributor.author	Shewade, D G	-
dc.contributor.author	Ramaswamy, S	-
dc.date.accessioned	2013-11-19T06:09:15Z	-
dc.date.available	2013-11-19T06:09:15Z	-
dc.date.issued	2001-05	-
dc.identifier.issn	0975-1009 (Online); 0019-5189 (Print)	-
dc.identifier.uri	http://hdl.handle.net/123456789/23755	-
dc.description	476-478	en_US
dc.description.abstract	Metoclopramide, a prokinetic drug, has been documented to produce antinociceptive response in animal models through opioid pathways. Morphine has been shown to act through ATP sensitive potassium channels ( KATP) to produce antinociceptive response. However, such a possibility has not been examined for metoclopramide. The present study investigated this using pharmacological tools. Acetic acid induced abdominal constriction assay procedure was utilized to assess antinociception. The results confirmed that metoclopramide has antinociceptive response. Glibenclamide, a K_ATPchannel blocker, pretreatment antagonized this response. Where as, in minoxidil pretreated animals, metoclopramide elicited an enhanced antinociceptive response. Glibenclamide and minoxidil, which are known K_ATP channel blocker and opener respectively, interfered with metoclopramide antinociception. These finding are suggestive of a role for K_ATP channels in metoclopramide antinociception in mice.	en_US
dc.language.iso	en_US	en_US
dc.publisher	NISCAIR-CSIR, India	en_US
dc.rights	CC Attribution-Noncommercial-No Derivative Works 2.5 India	en_US
dc.source	IJEB Vol.39(05) [May 2001]	en_US
dc.title	Effect of ATP sensitive potassium channel modifiers on antinociceptive effect of metoclopramide	en_US
dc.type	Article	en_US
Appears in Collections:	IJEB Vol.39(05) [May 2001]

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