Phostoxin-induced biochemical and pathomorphological changes in rabbits

Abstract

The effect of chronic phostoxin administration on some tissue ATPases, hematology and tissue histopathology was investigated using a combination of gravimetric, enzymatic, colorimetric and histological procedures in New Zealand White rabbits after 2 weeks administration of 0.8 mg phostoxin/kg body weight/day, po. The phostoxin treatment led to significant decreases in Na⁺-K⁺ ATPase activities in renal, hepatic and cardiac tissues. Similar decreases were obtained in the activities of Ca²⁺-ATPase and Mg²⁺-ATPase in liver. In addition, the phostoxin-toxified rabbits manifested significant decreases in hematocrit, red blood cell count, hemoglobin and platelets. Histological examination of the tissues revealed pronounced degenerative changes in liver, heart and kidney.