Effect of nimesulide co-administration on pharmacokinetics of lithium

Abstract

In a crossover study,<i> </i>lithium was given orally at a dose of 56 mg/kg, prepared as suspension (0.5%) in carboxymethyl cellulose (CMC) and blood samples (l ml) collected after 0-24 hr after drug administration. After a washout period of two weeks, nimesulide (10mg/kg) was administered alongwith lithium (56 mg/kg) and blood samples were drawn at the same time intervals (0-24 hr) after drug administration. Plasma was separated and assayed for

lithium by M 654 Na⁺/K⁺/Li⁺ analyzer and various pharmacokinetic parameters were calculated. C_max, Kel, t_1/2el and AUC_0-α of lithium were significantly increased when nimesulide was administered along with lithium as compared to control group.