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http://nopr.niscpr.res.in/handle/123456789/23850| Title: | 99mTc-Iabeled field bean protease inhibitor can function as an efficient tumor detecting agent |
| Authors: | Murugesan, S Banerji, A P Noronha, O P D Samuel, A M Fernandes, A O |
| Issue Date: | Aug-2001 |
| Publisher: | NISCAIR-CSIR, India |
| Abstract: | Purified field bean protease inhibitor (FBPI) was labeled with 99mTcO4- to ascertain its ability to locate tumors in tumor-bearing rat models. The labeling was done with Sn2+ as a reducing agent and the yield was 95%. It was stable for 2 hr at ambient temperature. The biodistribution study of the intravenously injected radiolabeled FBPI in normal Wistar rats at various time intervals showed a rapid blood clearance from the systemic circulation (~5hr). The complex was predominantly excreted through the renal and the hepatobiliary systems. In vivo distribution and scintiimaging of 99mTc-FBPI were carried out in rats bearing carcinogen-induced mammary tumor or transplanted C6-gliomas. The results obtained were compared with conventional tumor-seeking radiopharmaceuticals such as 99mTc-(V)dimercaptosuccinic acid (DMSA), 201Thallous chloride (TICI) and 9mTc-Citrate. The tumor to muscle (T/M) ratios obtained with 99mTc-FBPI in rat C6 glioma was nearly 2 to 5-fold higher than obtained with all the three conventional tumor-seeking agents. The T/M ratio obtained with 99mTc-FBPI in rat mammary tumor on the other hand appeared to be 2-3-fold higher than noted with 99mTc(V)-DMSA and 201TICI. The ratio was however comparable with that obtained with 99mTc-Citrate. The study indicated that 999mTc -FBPI has the specific potentials for imaging gliomas and possibly other tumors as well. |
| Page(s): | 742-747 |
| ISSN: | 0975-1009 (Online); 0019-5189 (Print) |
| Appears in Collections: | IJEB Vol.39(08) [August 2001] |
Files in This Item:
| File | Description | Size | Format | |
|---|---|---|---|---|
| IJEB 39(8) 742-747.pdf | 1.36 MB | Adobe PDF | View/Open |
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