Please use this identifier to cite or link to this item:
http://nopr.niscpr.res.in/handle/123456789/23983| Title: | Damage induction by direct electric current in tumoural target cells |
| Authors: | Holandino, Carla Veiga, Venicio F Capella, Marcia M A Menezes, Salatiel Alviano, Celuta S |
| Issue Date: | Jun-2000 |
| Publisher: | NISCAIR-CSIR, India |
| Abstract: | Damage induction to tumour target cells (P815) by direct electric current (DC) was investigated. A 6 min treatment of P815 cells with DC generated decreased levels of cell viability and proliferation. The ultrastructural analysis of DC-treated cells revealed the presence of blebs, loss of cell surface filopodia, and ruptures in cell membrane. Mitochondrial alterations, swelling of cells, cytoplasmic matrix rarefaction, and cellular debri formation were also observed. The study shows that tumoural target cells can be damaged by direct electric current and this approach may provide means to understand the mechanism of tumour regression induced by electrochemical therapy. |
| Page(s): | 554-558 |
| ISSN: | 0975-1009 (Online); 0019-5189 (Print) |
| Appears in Collections: | IJEB Vol.38(06) [June 2000] |
Files in This Item:
| File | Description | Size | Format | |
|---|---|---|---|---|
| IJEB 38(6) 554-558.pdf | 1.22 MB | Adobe PDF | View/Open |
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