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| DC Field | Value | Language |
|---|---|---|
| dc.contributor.author | Bimal, Sanjiva | - |
| dc.contributor.author | Bagchi, A K | - |
| dc.contributor.author | Das, V | - |
| dc.contributor.author | Sinha, P K | - |
| dc.contributor.author | Lal, C S | - |
| dc.contributor.author | Ranjan, A | - |
| dc.contributor.author | Gupta, A K | - |
| dc.contributor.author | Kar, S K | - |
| dc.date.accessioned | 2013-11-21T10:50:52Z | - |
| dc.date.available | 2013-11-21T10:50:52Z | - |
| dc.date.issued | 2001-09 | - |
| dc.identifier.issn | 0975-1009 (Online); 0019-5189 (Print) | - |
| dc.identifier.uri | http://hdl.handle.net/123456789/24003 | - |
| dc.description | 878-882 | en_US |
| dc.description.abstract | In a bid to characterize the antigens and immunization mechanisms which may be used to produce a protective response against L donovani, role of lipid associated polysaccharide (LPS) antigen and whole antigen was evaluated. BALB/C mice were immunized with whole or LPS antigen in combination with one of three putative adjuvents (anti CD-2 antibody I FIA I 0.85 % Saline). LPS antigen emulsified in anti CD-2 antibody was found to induce significant antibodies in mice on day 28 against challenge with lethal dose of L donovani. Immunoprophylactic properties of LPS and whole antigen was investigated on day 40 through cytokine elicitation (IL-2), MIF) in culture supernatants of spleen cells, but before that MHC-II expressed on macrophage was studied. The LPS antigen in combination with anti CD-2 antibody was found to be most immuno-reactive inducing higher MHC-II expression on macrophages which was associated with substantial rise in the level of MIF and IL-2. It coincided with decline in antibody titre in 100% mice immunized with LPS antigen while Leishmania injected as whole antigen failed to induce specific macrophage and T-cell response with all the above formulations. We surmise from our data that lipid associated polysaccharide antigen linked to anti CD-2 antibody has potential for eliciting protective immunity against Leishmania. | en_US |
| dc.language.iso | en_US | en_US |
| dc.publisher | NISCAIR-CSIR, India | en_US |
| dc.rights |  CC Attribution-Noncommercial-No Derivative Works 2.5 India | en_US |
| dc.source | IJEB Vol.39(09) [September 2001] | en_US |
| dc.title | Effect of immunization with lipid associated polysaccharide antigen and anti CD-2 antibodies on class II MHC expression and cellular immune response in BALB/C mice infected with Leishmania donovani | en_US |
| dc.type | Article | en_US |
| Appears in Collections: | IJEB Vol.39(09) [September 2001] | |
Files in This Item:
| File | Description | Size | Format | |
|---|---|---|---|---|
| IJEB 39(9) 878-882.pdf | 1.45 MB | Adobe PDF | View/Open |
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