<span style="font-size: 21.5pt;mso-bidi-font-size:14.5pt;font-family:"Times New Roman","serif"">Electromagnetic exposure effects the hippocampal dentate cell proliferation in gerbils <i>(Meriones unguiculatus)</i> </span>

Abstract

<span style="font-size: 16.0pt;mso-bidi-font-size:9.0pt;font-family:" times="" new="" roman","serif""="">The chronic effect on hippocampal neurogenesis after exposure (30 min/day for 14 days) to a high frequency (35,53 kHz) electromagnetic field, double modulated at extremely low frequencies (ELF; 1, 8, 12, 29 and 50 Hz), was studied in young adult gerbils. Immediately after the last exposure proliferation of dentate granule cells was identified by <i>in vivo </i>labeling with 5-bromo-2-desoxyuridine (BrdU). Exposure to 1, 29 and <span style="font-size:15.5pt;mso-bidi-font-size:8.5pt;font-family:" times="" new="" roman","serif";="" mso-bidi-font-style:italic"="">50<i> </i><span style="font-size:16.0pt; mso-bidi-font-size:9.0pt;font-family:" times="" new="" roman","serif""="">Hz resulted in a statistically significant reduction of cell proliferation rates, but only the 50Hz-group manifested the effect highly significantly (-29,3 <span style="font-size:15.0pt;mso-bidi-font-size:8.0pt;font-family:" arial","sans-serif""="">%). <span style="font-size:16.0pt;mso-bidi-font-size:9.0pt;font-family:" times="" new="" roman","serif""="">On the other hand, gerbils exposed to 8 and 12 Hz showed no significant change of postmitotic cell proliferation as compared with the sham treated controls. The results suggest that the effects of ELF on the granule cell proliferation are mediated by neurotmnsmitters and hormones which regulate hippocampal neurogenesis.

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