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http://nopr.niscpr.res.in/handle/123456789/24078| Title: | Effect of casein diet on gonadotropin releasing hormone antagonist induced changes in adrenal gonadal functions in male rats |
| Authors: | Biswas, N M Chaudhuri, Gargi Ray Chattopadhyay, A Sarkar, M |
| Issue Date: | Dec-2001 |
| Publisher: | NISCAIR-CSIR, India |
| Abstract: | Adult male rats received daily injections (sc) of gonadotropin releasing hormone antagonist (0.2 mg/kg-1.day-1 ) for 21 days when they were sacrificed on day 22, adrenal weight, adrenal Δ5-3β (delta 5-3beta) hydroxysteroid dehydrogenase (Δ5-3β-HSD) activity and serum level of corticosterone were increased significantly while testicular 17β(17beta) hydroxysteroid dehydrogenase ( 17β-HSD) activity and serum level of testosterone and spermatogenesis were decreased in the rats fed on 5% casein diet. GnRH antagonist treated rats fed on 20% casein diet, resulted significant decrease in adrenal weight , serum corticosterone and adrenal Δ5-3β HSD activity while testicular 17β-HSD activity serum testosterone levels and the weights of sex organs were increased with respect to anti GnRH treated rats fed on 5% casein diet. But the GnRH antagonist treated rats fed on 20% casein diet showed decreased spermatogenesis quantitatively and sperm count appeared similar to anti GnRH treated rats fed on 5% casein diet. These results indicate that high casein diet protects adrenocortical activity and stimul ates testosterone synthesis without effecting spermatogenic arrest in GnRH antagonist treated rats. It may be concluded that GnRH antagonist in presence of high milk protein diet may be considered to be a suitable antihormone in the development of an ideal male contraceptive. |
| Page(s): | 1249-1253 |
| ISSN: | 0975-1009 (Online); 0019-5189 (Print) |
| Appears in Collections: | IJEB Vol.39(12) [December 2001] |
Files in This Item:
| File | Description | Size | Format | |
|---|---|---|---|---|
| IJEB 39(12) 1249-1253.pdf | 1.37 MB | Adobe PDF | View/Open |
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