Maharishi Amrit Kalash, an ayurvedic medicinal preparation, enhances cholinergic enzymes in aged guinea pig brain

Abstract

<span style="font-size: 15.5pt;mso-bidi-font-size:8.5pt;font-family:" times="" new="" roman","serif""="">The effect of orally fed Maharishi Amrit Kalash was examined on the activities of cholinergic enzymes in the guinea pig brain. The activity of the cholinergic enzymes viz. choline-acetyl transferase and acetylcholinesterase enzymes was found to be reduced significantly (<i style="mso-bidi-font-style:normal">P</i><0.05) in the various regions of CNS of the aged guinea pigs. Oral administration of MAK(500 mg/kg body weight daily) for 2 months significantly increased (<i style="mso-bidi-font-style:normal">P</i><0.05) the activity of choline acetyl transferase and acetylcholinesterase in the older animals. The present study indicates that this food supplement can <span style="font-size:15.5pt; mso-bidi-font-size:8.5pt;font-family:" arial","sans-serif""="">be <span style="font-size:15.5pt;mso-bidi-font-size:8.5pt;font-family:" times="" new="" roman","serif""="">helpful in alleviating the cholinergic deficits in the old age.

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