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http://nopr.niscpr.res.in/handle/123456789/24128| Title: | In vitro schizontocidal activity of standard antimalarial drugs on chloroquine-sensitive and chloroquine-resistant isolates of Plasmodium falciparum |
| Authors: | Sharma, Poonam Pillai, C R Sharma, Jayashri Devi |
| Issue Date: | Nov-2000 |
| Publisher: | NISCAIR-CSIR, India |
| Abstract: | The expanding foci of multiple drug resistant malaria and emergence of different strains requires the reassessment of antimalarial activity with various drugs. In vitro response of a chloroquine sensitive and a chloroquine resistant isolate of P. falciparum to a group of 6 quinine derived and 3 artemisinin derived standard drugs has been screened, to evaluate schizontocidal activtiy of the drugs. In a conventional test system the IC50s were derived from the log dose response curves and evaluated by a rigorous statistical interpretation. Analysis by Tukey's test was significant for the quinine related drugs (Q≤0.01) and excludes the statistical significance of artemisinin related drugs in these isolates. The dose-responses of these two isolates vary with quinine derivatives, with some overlap at lower doses for the sensitive isolate than for the resistant one which manifests at higher doses. |
| Page(s): | 1129-1133 |
| ISSN: | 0975-1009 (Online); 0019-5189 (Print) |
| Appears in Collections: | IJEB Vol.38(11) [November 2000] |
Files in This Item:
| File | Description | Size | Format | |
|---|---|---|---|---|
| IJEB 38(11) 1129-1133.pdf | 1.17 MB | Adobe PDF | View/Open |
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