Drug release and antimicrobial studies on chitosan-coated cotton yarns

Abstract

Cotton yarns coated with chitosan have been prepared by the oxidation of cotton yarns with sodium periodate at 60°C in water and subsequent treatment with a solution of chitosan in aqueous acetic acid. Infrared spectra of the chitosan-coated cotton yarn show the formation of Schiffs base between the chitosan and the oxidized cellulose. The chitosan-coated yarns

have been further immobilized with tetracycline drug and the effect of drug concentration and treatment time on drug release characteristics and antimicrobial activity studied. The study shows good drug release characteristics and antimicrobial activity against <i>E.coli</i> and <i>S</i>. <i>aureus</i>.