A Review on Microbial Alkaline Proteases

Abstract

Alkaline proteases are of considerable interest in view of their activity and stability at alkaline pH. This review, describes the proteases that can resist extreme alkaline environments produced by a wide range of alkalophilic microorganisms. Different isolation methods which enable the screening and selection of promising organisms for industrial production are discussed. The various nutritional and environmental parameters affecting the production of alkaline proteases are delineated. The production of proteases by free and immobilized whole cells is discussed. The purification, properties, and applications of these proteases are also discussed.