Synthesis, antibacterial and antifungal activities of some new azo anils containing pyrazole moiety

Abstract

A series of azo compounds namely 3-(Phenylazo) benzaldehyde <b>1a-f</b>, 3-(4-Nitrophenylazo) benzaldehyde <b>3a-f</b> and 3-(1,5-Dimethyl–3-oxo-2-phenyl-2,3-dihydro-1<i>H</i>-pyrazol-4-yl-azo) benzaldehyde <b>6</b> were synthesized and then azo anils <i>viz.</i> 3-(Phenylazo)-1,5 dimethyl-3-oxo-2-phenyl-2,3-dihydro-1<i>H</i> pyrazol-4-yl imino methyl benzene <b>2a-f, 4a-f </b>and<b> 7-9</b> have been synthesized from azo compounds by reacting with corresponding amines. All the compounds synthesized by conventional method are also prepared by using microwave irradiation method and are characterized by spectroscopic techniques (UV, FTIR and ¹H NMR). The synthesized compounds have been screened for antimicrobial activity against bacteria viz. <i>Mesorhizobium </i>sp.<span style="mso-bidi-font-style:italic">,<i> Bacillus </i>sp. and<i> Pseudomonas </i>sp<i>.</i><span style="mso-bidi-font-style:italic">, fungus (<i>Ascochyta blight)</i> and yeast (<i>Sacchromycis cerevisiae)</i>. The azo anils show minor to moderate activity against bacteria and no activity against fungus and yeast. The activity shown by some compounds is due to substitution of chloro, methoxy or nitro group on phenyl ring or due to some heterocyclic moiety.

</span></span>