Please use this identifier to cite or link to this item:
http://nopr.niscpr.res.in/handle/123456789/26645| Title: | Preparation and Evaluation of Solvent Deposited Systems of Felodipine |
| Authors: | Shirsand, S B Swamy, P V Babu, G V Murali Mohan Murthy, K V Ramana |
| Issue Date: | Dec-2000 |
| Publisher: | NISCAIR-CSIR, India |
| Abstract: | Solvent deposited (SD) systems of felodipine were prepared with biologically inactive carriers like microcrystalline cellulose (MCC), lactose, potato starch (PS), and aerosil in different ratios. These systems were evaluated for drug content uniformity, drug carrier interactions, and drug release profiles. Drug-carrier interactions were evaluated by using Differential Scanning Calorimetry (DSC), IR, and TLC. The results of drug-carrier interaction studies indicated that there was no interaction between the drug and the carrier. Release of drug from SD system was markedly increased than that of the corresponding physical mixture. The increase in the order of dissolution rate of felodipine from SD systems was: MCC > aerosil >PS > lactose. |
| Page(s): | 1044-1046 |
| ISSN: | 0975-1084 (Online); 0022-4456 (Print) |
| Appears in Collections: | JSIR Vol.59(12) [December 2000] |
Files in This Item:
| File | Description | Size | Format | |
|---|---|---|---|---|
| JSIR 59(12) 1044-1046.pdf | 517.76 kB | Adobe PDF | View/Open |
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