Formation of New Series of Heterocyclic Thiazolidine and its Arailidine Compounds and Reactions Related to Antifungal, Antipyretic and Quantitative Structural Activity

Abstract

Ethyl-(5-nitrobenzenemedazole)-acetate (1) is obtained from electron loving substitution in underflow condition of 5-nitrobenzemedazole, on ammonification with hydrazine acetohydrazaido-5-nitrobenzemedazole (2) is obtained. Arylidin-(5-nitrobenzemedazole)-amydyl (3) is obtained on condensation with various substituted carbonyls of the compound (2). (Substituted aryl)-3-(5- nitrobenzemedazole) -aceta amydyl-4-oxy-thiozoledenes (4) is obtained when reacted with thioglycolic acid of compound (3). (Substituted aryl) -3-(5- nitrobenzemedazole)- aceto amydyl-5- arylidins-4-oxo-thiozolidins (5) is obtained on reacting again in the presence of sodium from different substituted carbonyls of compound (4). Purity of compounds is calculated with chromatographical method and structural approval was done by spectrometer and chemical analysis. On antifungal and antipyretic study of all compounds obtained from above methods, biological activity has been indicated. Study of QSAR of biologically active compounds are being carried out with the help of computer.