Insulin secreting and α-glucosidase inhibitory activity of hexane extract of <i style="mso-bidi-font-style:normal">Annona squamosa</i> Linn. in streptozotocin (STZ) induced diabetic rats

Abstract

The hexane extract of <i style="mso-bidi-font-style:normal">A. squamosa<span style="mso-bidi-font-style: italic"> </span></i><span style="mso-bidi-font-weight:bold; mso-bidi-font-style:italic" lang="EN-GB">(ASHE) in 100 and 400 mg/kg body weight dose raised the insulin level when compared with Glimepiride (1 mg/kg) and also inhibited α-glucosidase activity when compared with Acarbose (10 mg/kg) in streptozotocin induced diabetic rats. <span style="mso-bidi-font-weight: bold">The <span style="mso-bidi-font-style:italic">ASHE significantly reduced peak blood glucose (Gp₃₀) and area under curve (AUC) in diabetic rats in oral glucose (OGTT) and oral sucrose (OSTT) tolerance test, but there was more reduction of Gp₃₀ value than AUC in OSTT. Thus, it can be suggested that the ASHE, has hypoglycemic role at 2 levels, i.e. it acts as secretagogue and also inhibits the intestinal enzymes, responsible for glucose metabolism.<span style="mso-bidi-font-weight:bold">

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