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dc.contributor.authorManoharan, S-
dc.contributor.authorPanjamurthy, K-
dc.contributor.authorMenon, Venugopal P-
dc.contributor.authorBalakrishnan, S-
dc.contributor.authorAlias, Linsa Mary-
dc.description.abstractWith an aim to investigate the protective effect of Withaferin-A on 7,12-dimethylbenz[a]anthracene (DMBA) induced oral carcinogenesis in Syrian golden hamsters, tumour incidence, tumour volume and tumour burden and status of detoxication agents, lipid peroxidation and antioxidants in DMBA administered (3 times/week for 14 weeks) hamsters were assessed. Hundred percent tumour formation in DMBA alone administered animal was observed. Oral administration of Withaferin-A (20 mg/kg body weight) to DMBA administered animals for 14 weeks completely prevented the tumour incidence, tumour volume and tumour burden. Also, Withaferin-A showed significant anti-lipid peroxidative and antioxidant properties and maintained the status of phase-I and phase-II detoxication agents during DMBA-induced oral carcinogenesis. The results thus indicate that the protective effect of Withaferin-A is probably due to its anti-lipid peroxidative and antioxidant functions as well as modulating effect on carcinogen detoxication during DMBA-induced oral carcinogenesis.en_US
dc.sourceIJEB Vol.47(1) [January 2009]en_US
dc.subjectDetoxication agentsen_US
dc.subjectLipid peroxidationen_US
dc.subjectOral canceren_US
dc.titleProtective effect of Withaferin-A on tumour formation in 7,12-dimethylbenz[a]anthracene induced oral carcinogenesis in hamstersen_US
Appears in Collections:IJEB Vol.47(01) [January 2009]

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