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http://nopr.niscpr.res.in/handle/123456789/29045| Title: | Anti-hyperglycemic activity of Rutin in streptozotocin-induced diabetic rats: An effect mediated through cytokines, antioxidants and lipid biomarkers |
| Authors: | Niture, Netaji T Ansari, Ansar A Naik, Suresh R |
| Keywords: | Antidiabetic activity;Antioxidants;Lipid profile;Pro-inflammatory cytokines;Rutin;Streptozotocin |
| Issue Date: | Jul-2014 |
| Publisher: | NISCAIR-CSIR, India |
| Abstract: | Administration of rutin (50 and 100 mg/kg) and pioglitazone (10 mg/kg) orally for 3 weeks treatment significantly improved body weight, reduced plasma glucose and glycosylated hemoglobin, pro-inflammatory cytokines (IL-6 and TNF-α), restored the depleted liver antioxidant status and serum lipid profile in high fat diet + streptozotocin induced type 2 diabetic rats. Rutin treatment also improved histo-architecture of ß islets and reversed hypertrophy of hepatocytes. Rutin exhibited significant antidiabetic activity, presumably by inhibiting inflammatory cytokines, improving antioxidant and plasma lipid profiles in High fat diet + streptozotocin induced type 2 diabetic model and may be useful as a diabetic modulator along with standard antidiabetic drugs. However, such effects need to be confirmed on human subjects in clinical condition. |
| Page(s): | 720-727 |
| ISSN: | 0975-1009 (Online); 0019-5189 (Print) |
| Appears in Collections: | IJEB Vol.52(07) [July 2014] |
Files in This Item:
| File | Description | Size | Format | |
|---|---|---|---|---|
| IJEB 52(7) 720-727.pdf | 768.98 kB | Adobe PDF | View/Open |
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