<i><span style="font-size:15.0pt;font-family: "Times New Roman";mso-fareast-font-family:"Times New Roman";mso-bidi-font-family: "Times New Roman";mso-ansi-language:EN-US;mso-fareast-language:EN-US; mso-bidi-language:AR-SA" lang="EN-US">In vitro</span></i><span style="font-size: 15.0pt;font-family:"Times New Roman";mso-fareast-font-family:"Times New Roman"; mso-bidi-font-family:"Times New Roman";mso-ansi-language:EN-US;mso-fareast-language: EN-US;mso-bidi-language:AR-SA" lang="EN-US"> antioxidant studies on diselenodinicotinamide: A potent GPx mimic</span>

Abstract

Multifunctional biological activities of a<span style="font-size:9.0pt;mso-bidi-font-size:12.0pt" lang="EN-US"> glutathione peroxidase mimic, diselenodi<span style="font-size:9.0pt;mso-bidi-font-size:12.0pt" lang="EN-US">nicotinamide<span style="font-size:9.0pt;mso-bidi-font-size:12.0pt" lang="EN-US"> (2, 2′-disele<span style="font-size:9.0pt;mso-bidi-font-size:12.0pt" lang="EN-US">nobis- [3-amidopyridine]) (SNA), as an antioxidant are evaluated for its ability to inhibit free radical induced damage to biomolecules like lipids and DNA. Damage to lipids has been assayed by lipid peroxidation and DNA damage by gel-electrophoresis using AAPH or γ-radiation induced damage. The results indicate that SNA, at micro-molar concentration, protects both lipids and DNA from AAPH and γ-radiation induced damage. Also, SNA is non-toxic to normal cells but slightly toxic to cancer cells. These results coupled with its water solubility and GPx mimicking activity make SNA a potential candidate for future <i>in vivo</i> studies as an antioxidant.

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