Substituted 1,2,4-triazoles and thiazolidinones from fatty acids: Spectral characterization and antimicrobial activity

Abstract

The compounds (Z)-5-(alk-9/8-en-1-yl)-4-phenyl-1,2,4-triazole-3-thiones, (Z)-5-(8/11-hydroxyalk-11/8-en-1-yl)-4-phenyl-1,2,4-triazole-3-thiones, (Z)-N-[2-(phenylimino)-3-yl]-alk-9-enamide-4-thiazolidinone and (Z)-9/12-hydroxy-N-[2-(phenylimino)-3-yl]alk-12/9-enamide-4-thiazolidinone have been synthesized from different fatty acid hydrazides. The structural elucidation of these compounds is based on IR, ¹H NMR, ¹³C NMR, mass spectral data and elemental analysis. These compounds have been tested for their antibacterial activity against Escherchia coli, Enterobacter aerogenes, Staphylococcus aureus and Salmonella typhi by cup-plate method.