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http://nopr.niscpr.res.in/handle/123456789/29515| Title: | Hypoglycaemic effect of aqueous extracts of natural plants and callus cultures of Munronia pinnata (Wall.) W.Theob. in Wistar rats |
| Authors: | Hapuarachchi, SD Suresh, TS Senarath, WTPSK |
| Keywords: | Munronia pinnata;Hypoglycaemic;Anti diabetic;In vitro propagation;Callus cultures |
| Issue Date: | Oct-2014 |
| Publisher: | NISCAIR-CSIR, India |
| IPC Code: | Int. Cl.8: A61K 36/00, A01D 20/00, A01D 16/02, A01G |
| Abstract: | Munronia pinnata (MP) is one of the most demand herbs in the Sri Lankan drug market which has been used for various ailments in folk medical practice in Sri Lanka. There is an urgent need to adapt ex situ conservation methods via in vitro propagation techniques due to the high demand and overharvesting of this herb. The possible use of calli as a substitute for whole plants has been queried. The purpose of the present study was thus to compare the hypoglycaemic effect of aqueous extracts of natural plant (MPaq) and calli (MPCaq) of MP in healthy and alloxan induced diabetic rats. Natural plants and 3-months’ old calli of MP were used for the preparation of aqueous extracts. Effect of graded doses of both extracts of MP on serum glucose (SGL) of normal rats was studied. In case of diabetic rats, the results were compared with the reference drug glibenclemide and safety assessment of extracts was evaluated following administration for three months. Both MPaq and MPCaq extracts were showed reduction of the serum glucose levels of normal and diabetic rats. The reduction of SGL by MPaq and MPCaq were showed higher (24% and 18%) as compared to that of glibenclamide (16%) in diabetic animals. This study has been able to demonstrate that both MP extracts exhibits statistically significant hypoglycaemic effect were compared to the reference drug and proves the scientific rationale for its use as a popular folk medicine for diabetes. |
| Page(s): | 659-664 |
| ISSN: | 0975-1068 (Online); 0972-5938 (Print) |
| Appears in Collections: | IJTK Vol.13(4) [October 2014] |
Files in This Item:
| File | Description | Size | Format | |
|---|---|---|---|---|
| IJTK 13(4) 659-664.pdf | 147.4 kB | Adobe PDF | View/Open |
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