<i style="mso-bidi-font-style:normal"><span style="font-size:13.0pt; mso-bidi-font-weight:bold" lang="EN-GB">In vitro</span></i><span style="font-size:13.0pt;mso-bidi-font-weight:bold" lang="EN-GB"> anticancer activity of extracts of <i style="mso-bidi-font-style:normal">Mentha</i> Spp. against human cancer cells </span>

Abstract

<i style="mso-bidi-font-style:normal">In vitro</i> anticancer potential of methanolic and aqueous extracts of whole plants of <i style="mso-bidi-font-style:normal">Mentha arvensis, M. longifolia, M. spicata</i> and <i style="mso-bidi-font-style:normal">M. viridis</i> at concentration of 100 µg/ml was evaluated against eight human cancer cell lines — A-549, COLO-205, HCT-116, MCF-7, NCI-H322, PC-3, THP-1 and U-87MG from six different origins (breast, colon, glioblastoma, lung, leukemia and prostate) using sulphorhodamine blue (SRB) assay. Methanolic extracts of above-mentioned <i style="mso-bidi-font-style:normal">Mentha </i>Spp. displayed anti-proliferative effect in the range of 70-97% against four human cancer cell lines, namely COLO-205, MCF-7, NCI-H322 and THP-1; however, aqueous extracts were found to be active against HCT-116 and PC-3. The results indicate that <i style="mso-bidi-font-style:normal">Mentha </i>Spp. contain certain constituents with cytotoxic properties which may find use in developing anticancer agents.